Table 1

Annualized lifetime rates of progression and levels of disability and health status in rheumatoid arthritis

Variable

All patients

(N = 18,485)

Rate of progression

Rate (95% CI)

Values at RA duration

Of 0 years (onset)*

Mean (95% CI)

Values at RA duration of 10 years*

Mean (95% CI)

Values at RA duration of 20 years

Mean (95% CI)


HAQ

0.016 (0.015, 0.017)

0.84 (0.83, 0.86)

1.00 (0.99, 1.01)

1.16 (1.15, 1.18)

PCS

-0.125 (-0.142, -0.108)

37.9 (37.6, 38.1)

36.6 (36.5, 36.8)

35.4 (35.2, 35.6)

MCS

0.047 (0.031, 0.063)

48.5 (48.3, 48.8)

49.0 (48.8, 49.1)

49.4 (49.4, 49.6)

EQ-5D

-0.001 (-0.001, -0.000)

0.748 (0.742, 0.754)

0.739 (0.736, 0.743)

0.731 (0.727, 0.735)


Positive rates indicate worsening HAQ disability. Negative rates indicate worsening health status for MCS, PCS, and EQ-5D. Values at 0, 10, and 20 years RA duration are estimated from the mixed model regression analysis.

HAQ, Health Assessment Questionnaire; PCS, SF-36 Physical Component Summary; MCS, SF-36 Mental Component Summary.

Wolfe and Michaud Arthritis Research & Therapy 2010 12:R35   doi:10.1186/ar2944

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