Table 1

Cytokine and chemokines that play a role in gouty inflammation

Cytokine

Actions contributing to gouty inflammation

Produced by

References


IL-1β

Endothelial adhesion

Monocyte, dendritic cells inflammatory macrophage

[11,12,20,25]

Endogenous pyrogen

TNFα

Cellular activation

Monocyte, macrophage, lining cell

[11,12]

Endothelial adhesion

Phagocytosis

IL-6

?

Monocyte, macrophage

[11,17]

Granulocyte colony-stimulating factor

Neutrophil survival and proliferation

Endothelium, macrophage

[11,17]

CXCL1 (KC, Groa)

Neutrophil chemotaxis

Macrophage, neutrophil

[11]

CXCL8 (IL-8)

Neutrophil chemotaxis

Macrophage, endothelium

[36,37]

CCL2 (monocyte chemoattractant protein-1)

Monocyte and dendritic cell chemotaxis

[11]

Mast cell degranulation

CCL3 (macrophage inflammatory protein-1)

Neutrophil chemotaxis

Monocyte, macrophage

[11]


Busso and So Arthritis Research & Therapy 2010 12:206   doi:10.1186/ar2952