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Editorial

Vasculogenesis in rheumatoid arthritis

Zoltán Szekanecz1* and Alisa E Koch23

Author Affiliations

1 Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Sciences Center, 98 Nagyerdei street, Debrecen, H-4032, Hungary

2 Veterans' Administration, Ann Arbor Healthcare System, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA

3 University of Michigan Health System, Department of Internal Medicine, Division of Rheumatology, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA

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Arthritis Research & Therapy 2010, 12:110  doi:10.1186/ar2943


See related research by Jodon de Villeroché et al., http://arthritis-research.com/content/12/1/R27

Published: 18 March 2010

Abstract

Decreased number and impaired functions of endothelial progenitor cells (EPCs) leading to impaired vasculogenesis have been associated with rheumatoid arthritis (RA). Defective vasculogenesis has also been implicated in premature atherosclerosis in RA. Recently, early-outgrowth monocytic and late-outgrowth hemangioblastic EPC subsets have been characterized. Hemangioblastic EPCs may exert increased numbers in active RA and may play a role in vascular repair underlying RA.