Table 5 |
|||
|
Patient characteristics of cases and matched controls |
|||
|
Cases (with incident malignancy) |
Matched controls |
P |
|
|
|
|||
|
N |
74 |
74 |
|
|
Characteristics at study entry |
|||
|
Females# n (%) |
52 (70.3) |
52 (70.3) |
n.a. |
|
Age# (mean, SD) |
61.3 (8.9) |
61.4 (8.5) |
0.97 |
|
Observation time# (years) (median, IQR) |
2.9 (1.8, 4.0) |
2.9 (1.6, 3.9) |
0.25 |
|
DAS28# (mean, SD) |
5.6 (1.0) |
5.7 (1.0) |
0.31 |
|
Smoking status# |
|||
|
Nonsmoker |
16 (21.6) |
16 (21.6) |
n.a. |
|
Smoker n (%) |
19 (25.7) |
19 (25.7) |
|
|
Unknown status n (%) |
39 (52.7) |
39 (52.7) |
|
|
Disease duration (years) (median, IQR) |
7 (3,14) |
9 (5,16) |
0.22 |
|
Functional status, FFbH (mean, SD) |
57.1 (22.3) |
63.2 (22.6) |
0.058 |
|
Characteristics at follow-up |
|||
|
DAS28 (mean, SD)$ |
5.0 (1.2) |
4.9 (1.2) |
0.41 |
|
Ever exposed to biologics n (%) |
44 (59.5) |
45 (60.8) |
1.0 |
|
Ever exposed to anti-TNFα agents & |
44 (59.5) |
44 (59.5) |
1.0 |
|
Ever exposed to anakinra& |
5 (6.8) |
5 (6.8) |
1.0 |
|
Among them |
|||
|
Cases with solid tumors (n = 68) |
|||
|
Ever exposed to biologics |
39 (57.4) |
43 (63.2) |
0.56 |
|
Ever exposed to anti-TNFα agents |
39 (57.4) |
42 (61.8) |
0.70 |
|
Ever exposed to anakinra |
5 (7.4) |
5 (7.4) |
1.0 |
|
Cases with non-Hodgkin's Lymphoma (n = 6) |
|||
|
Characteristics at study entry |
|||
|
Females# n(%) |
5 (83.3) |
5 (83.3) |
n.a. |
|
Age# (mean, SD) |
65.2 (6.5) |
66.8 (8.0) |
0.13 |
|
Disease duration |
5.5 (4,13) |
7 (5,11) |
0.53 |
|
Functional status, FFbH (mean, SD) |
52.8 (31.4) |
54.2 (27.5) |
0.90 |
|
DAS28# (mean, SD) |
5.9 (0.6) |
6.2 (0.5) |
0.29 |
|
Characteristics at follow-up |
|||
|
DAS28 (mean, SD)$ |
5.2 (0.7) |
5.5 (0.7) |
0.14 |
|
|
|||
|
Ever exposed to anti-TNFα agents |
5 (83.3) |
2 (33.3) |
0.38 |
|
|
|||
|
# matching criteria (further matching criteria not shown in the table = COPD, other chronic lung disease, chronic renal disease, chronic gastrointestinal disease, chronic liver disease, and psoriasis) &five cases and four controls received anti-TNFα agents and anakinra (at different points in time) $cases = mean of DAS28 values over time points until six months prior to the cancer diagnosis, matched controls: mean of DAS28 values over time points of the corresponding case |
|||
|
Strangfeld et al. Arthritis Research & Therapy 2010 12:R5 doi:10.1186/ar2904 |
|||
