Figure 2.

c-Fms inhibition reduces synovitis, pannus formation, and joint erosion in autoimmune arthritis. (a) Representative Toluidine blue-stained joint sections from DBA/1 mice in the collagen-induced arthritis (CIA) prevention study. Images are shown at × 100 magnification and are representative of at least two independent experiments. Histopathologic scores for synovitis, pannus formation, and joint erosion in (b) DBA/1 mice with CIA in the prevention study (vehicle, n = 10; 80 mg/kg GW2580, n = 10; 80 mg/kg imatinib, n = 10), (c) DBA/1 mice with CIA in the treatment study (vehicle, n = 8; 80 mg/kg GW2580, n = 8; 80 mg/kg imatinib, n = 8), (d) BALB/c mice with anti-collagen antibody-induced arthritis (CAIA) (vehicle, n = 5; 80 mg/kg GW2580, n = 5; 80 mg/kg imatinib, n = 5), and (e) BALB/c mice with K/BxN serum transfer arthritis (vehicle, n = 5; 80 mg/kg GW2580, n = 5; 80 mg/kg imatinib, n = 5). The data shown are representative of at least two independent experiments. Values are the mean ± standard error of the mean. *P < 0.05 compared with vehicle-treated mice.