Figure 1.

c-Fms inhibition prevents and treats autoimmune arthritis. Clinical arthritis scores (left panels) and paw thickness measurements (right panels) of arthritic mice treated with imatinib or GW2580. (a, b) Collagen-induced arthritis (CIA) prevention studies in DBA/1 mice; administration of vehicle (n = 12), 30 mg/kg GW2580 (n = 12), 80 mg/kg GW2580 (n = 12), or 80 mg/kg imatinib (n = 12) started 1 day before induction of CIA. (c, d) CIA treatment studies in DBA/1 mice; administration of vehicle (n = 15), 80 mg/kg GW2580 (n = 15), or 80 mg/kg imatinib (n = 15) started once CIA is established as indicated. (e, f) Anti-collagen antibody-induced arthritis (CAIA) prevention studies in BALB/c mice; administration of vehicle (n = 5), 80 mg/kg GW2580 (n = 5), or 80 mg/kg imatinib (n = 5) started 1 day before transfer of anti-collagen type II antibodies. (g, h) K/BxN prevention studies in BALB/c mice; administration of vehicle (n = 5), 80 mg/kg GW2580 (n = 5), or 80 mg/kg imatinib (n = 5) started 1 day before transfer of K/BxN serum. The data shown in (a-h) are representative of three independent experiments. Values are the mean ± standard error of the mean for the representative experiment shown. *P < 0.05, **P < 0.01 compared with vehicle-treated mice.