Table 2

Chronologic overview of literature describing the effect of mesenchymal stem cells on collagen-induced arthritis

MSC source

MSC administration



Reference

Organisma

Strainb

Organc

Transfectiond

Routee

Dosef

Timeg

Resulth


[26]

Mouse

C3

Cell line

n.a.

i.v.

1 × 106

0

0

21

0

4 × 106

0

0

21

-

IL-10

i.v.

1 × 106

0

0

[23]

Mouse

C57Bl/10

BM

n.a.

i.p.

5 × 106

0

+

21

+

[27]

Mouse

DBA/1

BM

n.a.

i.v.

1 × 106

21+28+35

0

IL-10

i.v.

1 × 106

21+28+35

+

[24]

Human

n.a.

Adipose

n.a.

i.p.

1 × 106

5 a.d.o.

+

Mouse

C57Bl/6

Adipose

n.a.

i.p.

1 × 106

5 a.d.o.

+

Mouse

DBA/1

Adipose

n.a.

i.p.

1 × 106

5 a.d.o.

+

[25]

Rat

n.s.

BM

n.a.

i.v.

2 × 106

1 a.d.o.

+


Mesenchymal stem cells (MSCs) in the studies described were isolated from different organismsa, strainsb, and organsc and transfected (interleukin-10 (IL-10)) or not (n.a.) with IL-10 expression vectorsd. MSCs were administered intravenously (i.v.) or intraperitoneally (i.p.)e at specified dosesf and administered at different time points (that is, days after immunizationg). hResults of the studies were summarized as follows: 0, no effect; -, worsening of symptoms; +, beneficial effect on arthritis symptoms. a.d.o., after disease onset; BM, bone marrow; n.a., not applicable; n.s., not specified.

Schurgers et al. Arthritis Research & Therapy 2010 12:R31   doi:10.1186/ar2939

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