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Table 2
Chronologic overview of literature describing the effect of mesenchymal stem cells on collagen-induced arthritis
	MSC source				MSC administration

Reference	Organism^a	Strain^b	Organ^c	Transfection^d	Route^e	Dose^f	Time^g	Result^h

[26]	Mouse	C3	Cell line	n.a.	i.v.	1 × 10⁶	0	0
							21	0
						4 × 10⁶	0	0
							21	-
				IL-10	i.v.	1 × 10⁶	0	0
[23]	Mouse	C57Bl/10	BM	n.a.	i.p.	5 × 10⁶	0	+
							21	+
[27]	Mouse	DBA/1	BM	n.a.	i.v.	1 × 10⁶	21+28+35	0
				IL-10	i.v.	1 × 10⁶	21+28+35	+
[24]	Human	n.a.	Adipose	n.a.	i.p.	1 × 10⁶	5 a.d.o.	+
	Mouse	C57Bl/6	Adipose	n.a.	i.p.	1 × 10⁶	5 a.d.o.	+
	Mouse	DBA/1	Adipose	n.a.	i.p.	1 × 10⁶	5 a.d.o.	+
[25]	Rat	n.s.	BM	n.a.	i.v.	2 × 10⁶	1 a.d.o.	+

Mesenchymal stem cells (MSCs) in the studies described were isolated from different organisms^a, strains^b, and organs^cand transfected (interleukin-10 (IL-10)) or not (n.a.) with IL-10 expression vectors^d. MSCs were administered intravenously (i.v.) or intraperitoneally (i.p.)^eat specified doses^fand administered at different time points (that is, days after immunization^g). ^hResults of the studies were summarized as follows: 0, no effect; -, worsening of symptoms; +, beneficial effect on arthritis symptoms. a.d.o., after disease onset; BM, bone marrow; n.a., not applicable; n.s., not specified.
Schurgers et al. Arthritis Research & Therapy 2010 12:R31 doi:10.1186/ar2939

Table 2