Table 2

Summary of included case-control studies and characteristics

Study, Year, Country

Subjects

Mean age

(year)

Mean duration (year)

Type of bisphosphonate

AF definition

Total AF events (n)

Variables matched and/or controlled

Quality assessment score§


Heckbert and colleagues [7], 2008, USA

1,685 women in a commercial health care system database

73

20

Alendronate

ICD-9 codes verified by medical records +/- EKG

719

Age, HTN, calendar year, osteoporosis, and any cardiovascular disease

4/2/3

Sorensen and colleagues [19], 2008, Denmark

81,640 women in the National Registry of Patients

>75

Not reported

Alendronate

Etidronate

ICD-8 and 10 codes

13586

Age, county, cardiovascular disease, renal failure, DM, HRT, fracture, cancer, alcoholism, pulmonary disease, anti-thyroid drugs, osteoporosis, steroid use, etc

3/2/3

Grosso and colleagues* [16], 2009, UK

2,195 women with AF in the UK General Practice Research Database

82

13

Alendronate

Risedronate

Diagnosis codes and Read codes

2195

Age+

3/2/3

Levesque and colleagues [18], 2009, Canada

63,843 adults (BIS users and raloxifene users) in the Quebec health database

75

4

Alendronate

Etidronatea

Risedronatea

Not reported

2149

Age, cohort entry year, follow-up, CAD, HTN, and use of HRT

N/A


AF, atrial fibrillation; BIS, bisphosphonates; CAD, coronary artery disease; DM, diabetes mellitus; EKG, electrocardiogram; HRT, hormone replacement therapy; HTN, hypertension; ICD, International Classification of Diseases.

* self-controlled case-series. + no other adjustment not needed in self-controlled study, N/A, not applicable (only the abstract was available at the time of this study), a risks specific to etidronate or risedronate not used in meta-analysis, § Methodologic quality assessment score based on Newcastle-Ottawa Scale [23]; selection (0 to 4), comparability (0 to 2), and outcome score (0 to 3) points with a higher score representing a better quality.

Kim et al. Arthritis Research & Therapy 2010 12:R30   doi:10.1186/ar2938

Open Data