Table 2 |
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|
Absolute number of stem cells and circulating endothelial progenitor cells in peripheral blood (cells per 106 lineage-negative mononuclear cells) |
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|
Cells per 106 Lin- mononuclear cells |
RA patients (n = 59) |
Controls (n = 36) |
P value |
|
|
|||
|
Lin-/7AAD-/CD34+/CD133+ |
0.0002 |
||
|
Median (range) |
2,484 (213-26,613) |
1,068 (123-2,270) |
|
|
25%-75% percentile |
1,141-5,943 |
610.5-1,575 |
|
|
Lin-/7AAD-/CD34+/VEGFR-2+ |
0.0026 |
||
|
Median (range) |
259 (27-588) |
103 (11-1,105) |
|
|
25%-75% percentile |
124-493 |
49.75-193.8 |
|
|
Lin-/7AAD-/CD133+/VEGFR-2+ |
0.0276 |
||
|
Median (range) |
151 (45-964) |
125 (25-555) |
|
|
25%-75% percentile |
93-387 |
99.25-192.8 |
|
|
Lin-/7AAD-/CD34+/CD133+/VEGFR-2+ (EPCs) |
0.0007 |
||
|
Median (range) |
112 (27-588) |
60 (5-275) |
|
|
25%-75% percentile |
53-227 |
26-109.8 |
|
|
Lin-/7AAD-/CD105+/CD133-/VEGFR-2+(CECs) |
0.1727 |
||
|
Median (range) |
173 (12-989) |
139 (30-426)a |
|
|
25%-75% percentile |
57-341 |
73-189 |
|
|
Ratio EPCs/CECs, median (range) |
1 (0.07-4.28) |
1 (0.2-2.02)a |
0.3946 |
|
|
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|
aCirculating endothelial cell (CEC) number has been evaluated in 15 healthy controls. 7AAD, 7-aminoactinomycin D; DAS-28, 28-joint disease activity score; EPC, endothelial progenitor cell; Lin-, lineage-negative; RA, rheumatoid arthritis; VEGFR-2, vascular endothelial growth factor receptor-2. |
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|
Jodon de Villeroché et al. Arthritis Research & Therapy 2010 12:R27 doi:10.1186/ar2934 |
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