Research article
Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment
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* Corresponding author: Cornelis L Verweij c.verweij@vumc.nl
1 Department of Pathology, VU University Medical Center, De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands
2 Current address: Department of Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
3 Department of Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
4 Department of Molecular Cell Biology & Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
5 Department of Rheumatology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
Arthritis Research & Therapy 2010, 12:R11 doi:10.1186/ar2912
Published: 22 January 2010Additional files
Additional file 1:
Information on real-time PCR assays. Primer sequences for quantitative real-time PCR and Pre-designed Taqman Gene Expression Assays used for Fluidigm's BioMark™ Real-Time PCR System.
Format: XLS Size: 24KB Download file
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Additional file 2:
Microarray data values of the individual 34 IFN response genes. Microarray data values (in log2) of the 34 IFN response genes measured in 15 RA patients before and one month after infliximab treatment including EULAR response.
Format: XLS Size: 47KB Download file
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Additional file 3:
qPCR values of the individual 15 IFN response genes. Gene expression values of 15 IFN response genes measured by Fluidigm's BioMark™ Real-Time PCR System. Expression values were measured before start of treatment, one, two, three and four months after start of therapy in 5 EULAR good responder patients and 5 EULAR poor responder patients.
Format: XLS Size: 68KB Download file
This file can be viewed with: Microsoft Excel Viewer