Table 1

Histological evaluation of arthritis in human tumor necrosis factor (TNF)-alpha transgenic mice immunized with TNF kinoid

Group

Number of mice

Inflammation score

Incidence

Destruction score

Incidence

TNF-K (3 injections, sacrifice at week 27)

8

0.1 ± 0.1^a

2/8^b

0.0 ± 0.0^a

1/8^c

TNF-K (3 injections without maintenance dose, sacrifice at week 45)

8

0.6 ± 0.2^d

6/8

0.2 ± 0.1^d

3/8

TNF-K (3 injections with maintenance dose, sacrifice at week 45)

7

0.5 ± 0.1^d

7/7

0.3 ± 0.1^d

5/7

Intermittent infliximab (sacrifice at week 45)

8

1.4 ± 0.1

8/8

0.9 ± 0.2

7/8

Phosphate-buffered saline (sacrifice at week 27)

8

1.6 ± 0.1

8/8

0.9 ± 0.2

7/8

The incidence of inflammation/destruction as evaluated by histology is the number of mice with a score of inflammation/destruction of at least 0.25. Results are given as mean ± standard error of the mean. ^aP < 0.05 versus phosphate-buffered saline (PBS); ^bP < 0.01 versus PBS; ^cP < 0.05 versus PBS; ^dP < 0.05 versus infliximab. TNF-K, tumor necrosis factor kinoid.

Delavallée et al. Arthritis Research & Therapy 2009 11:R195   doi:10.1186/ar2897