Table 2

Haplotype distribution in patients with AS and controls

Haplotypes

rs1264457/rs2074505/rs2074503/rs2269709

Random controls

HLA-B27 controls

P

HLA-B27

patients with AS

p1

p2

Non B*2709

(B*2709)

n = 135

n = 40

AAGA

0.42

0.52

(0.59)*

9 × 10^-4

0.68

2 × 10^-11

3 × 10^-4

GGAG

0.24

0.23

(0.16)

ns

0.12

1 × 10^-4

0.001

GGGA

0.14

0.10

(0.10)

ns

0.05

7 × 10^-4

ns

Others

0.20

0.15

(0.15)

ns

0.15

ns

ns

in brackets = haplotype frequencies referring to 40 HLA-B*2709 positive subjects which had been enclosed in the statistical analysis; p1 = HLA-B27 positive patients with AS vs random controls; p2 = HLA-B27 positive patients with AS vs the pool of the HLA-B27 positive controls. AS = ankylosing spondylitis.

Paladini et al. Arthritis Research & Therapy 2009 11:R171   doi:10.1186/ar2860