Figure 4.

Effect of IL-1Ra, dexamethasone and TNF inhibitor on matrix metalloproteinase-3. All three inhibitors decreased levels of (a) total matrix metalloproteinase (MMP)-3 activity and (b) active MMP-3 without modifying levels of (c) pro-MMP-3. Line in center of box, median; lower and upper borders of boxes, lower (Q1) and upper (Q3) quartiles; whiskers, minimum and maximum values; o, outliers (values exceeding 1.5 × (Q3 - Q1)).