Table 5

Bone remodeling signature

Set 1

Set 2

Gene symbol

Gene name

Fold change

Q (%)

Fold change

Q (%)

Function

BMP6

Bone morphogenetic protein 6

1.5

2.4

1.7

1.5

Involved in ossification, osteoblast differentiation

CTNNAL1*

Catenin (cadherin-associated protein), alpha-like 1

3.0

2.3

2.3

2.1

Analogous to α-catenin which inhibits β-catenin. Á catenin inhibits wnt/catenin pathway

KREMEN1

Kringle containing transmembrane protein 1

2.0

2.4

2.0

2.5

Negative regulator of wnt/catenin pathway

PCSK6

Proprotein convertase subtilisin/kexin type 6

3.1

2.4

2.0

1.8

Regulator of BMP6

*Secondary analysis indicates that expression level changes are more apparent in males.

Sharma et al. Arthritis Research & Therapy 2009 11:R168   doi:10.1186/ar2855