Table 4 |
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|
Genes differentially expressed comparing chondrocytes in culture obtained from osteoarthritic (OA) and normal donors (ND) |
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|
Functional annotation Gene title (Gene symbol) |
Accession number |
Fold change |
Signal |
|
|
|
||||
|
OA vs ND |
OA |
ND |
||
|
|
||||
|
Monolayer |
||||
|
ADAM metalloproteinase with thrombospondin type 1 motif, 1 (ADAMTS1) |
[GenBank:AF060152] |
-1.7 |
968.0 |
1925.2 |
|
Collagen, type III, alpha 1 (COL3A1) |
[GenBank:AU146808] |
2.2 |
564.3 |
258.7 |
|
Collagen, type V, alpha 3 (COL5A3) |
[GenBank:AI984221] |
2.9 |
977.6 |
392.1 |
|
Collagen, type XI, alpha 1 (COL11A1) |
[GenBank:BG028597] |
1.9 |
327.8 |
161.1 |
|
Cartilage link protein 1 (HAPLN1) |
[GenBank:NM_001884] |
1.8 * |
2640.7 |
1467.5 |
|
Cartilage oligomeric matrix protein (COMP) |
[GenBank:NM_000095] |
-6.1 * |
24.7 |
187.4 |
|
Dystonin (DST) |
[GenBank:BC004912] |
-2.0 |
729.4 |
1486.6 |
|
Fibronectin 1 (FN1) |
[GenBank:AJ276395] |
-3.1 |
441.9 |
1642.6 |
|
Matrix metalloproteinase 1 (MMP1) |
[GenBank:NM_002421] |
5.0 * |
857.0 |
200.5 |
|
Matrix metalloproteinase 2 (MMP2) |
[GenBank:NM_004530] |
-1.9 |
2300.1 |
3706.1 |
|
Matrix metalloproteinase 3 (MMP3) |
[GenBank:NM_002422] |
2.6 |
2496.8 |
1052.8 |
|
Periostin, osteoblast specific factor (POSTN) |
[GenBank:AY140646] |
1.9 |
6610.8 |
3544.5 |
|
SRY (sex determining region Y)-box 9 (SOX9) |
[GenBank:AI382146] |
-2.6 * |
123.0 |
281.2 |
|
Transforming growth factor, beta receptor II (TGFBR2) |
[GenBank:D50683] |
-1.8 |
970.0 |
1760.5 |
|
TIMP metalloproteinase inhibitor 3 (TIMP3) |
[GenBank:NM_000362] |
-2.1 |
524.5 |
1067.1 |
|
Scaffold |
||||
|
Collagen, type VI, alpha 1 (COL6A1) |
[GenBank:BE350145] |
1.6 |
1125.6 |
767.4 |
|
Collagen, type VIII, alpha 2 (COL8A2) |
[GenBank:AI806793] |
-1.5 |
749.8 |
1067.1 |
|
Catenin, beta 1 (CTNNB1) |
[GenBank:AF130085] |
1.8 |
1254.4 |
785.5 |
|
Dystonin (DST) |
[GenBank:BC004912] |
1.8 |
1969.3 |
1178.2 |
|
Fibulin 1 (FBLN1) |
[GenBank:Z95331] |
-1.3 |
557.5 |
728.4 |
|
Fibronectin 1 (FN1) |
[GenBank:W73431] |
3.5 |
1160.8 |
410.2 |
|
Homeobox A13 (HOXA13) |
[GenBank:BG289306 |
-2.1 |
30.5 |
62.8 |
|
Homeobox C6 (HOXC6) |
[GenBank:NM_004503] |
1.8 |
857.2 |
525.7 |
|
Latent transforming growth factor beta binding protein 1 (LTBP1) |
[GenBank:AI986120] |
1.6 |
997.6 |
646.6 |
|
Myocyte enhancer factor 2C (MEF2C) |
[GenBank:N22468] |
1.7 * |
498.1 |
296.5 |
|
Microfibrillar-associated protein 2 (MFAP2) |
[GenBank:NM_017459] |
-1.4 |
2875.4 |
4083.6 |
|
Tissue factor pathway inhibitor 2 TFPI2) |
[GenBank:AL574096] |
2.8 |
76.2 |
38.3 |
|
Transforming growth factor, beta receptor I (TGFBR1) |
[GenBank:AV700621] |
2.6 |
682.7 |
303.9 |
|
TIMP metalloproteinase inhibitor 3 (TIMP3) |
[GenBank:BF347089] |
-1.5 |
216.2 |
308.3 |
|
WNT1 inducible signaling pathway protein 3 (WISP3) |
[GenBank:AF143679] |
-2.0 |
318.5 |
549.8 |
|
|
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|
Genes were functionally filtered with regard to their association with skeletal development and extracellular matrix formation. For the complete list see Additional data file 1. * P < 0.05; ** P < 0.01; *** P < 0.001. |
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|
Dehne et al. Arthritis Research & Therapy 2009 11:R133 doi:10.1186/ar2800 |
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