Table 1

Odds ratios for having the metabolic syndrome in patients receiving methotrexate monotherapy compared with those not on methotrexate


NCEP 2004
NCEP 2001

OR (95% CI)
OR (95% CI)

n = 62
n = 62

Crude
0.415 (0.21-0.82),
0.368 (0.19-0.73),

P = 0.011
P = 0.004



Model a
0.421 (0.21-0.84),
0.373 (0.19-0.75),

P = 0.014
P = 0.006



Model b
0.468 (0.23-0.99),
0.408 (0.19-0.84),

P = 0.038
P = 0.015

Crude: Unadjusted model. Model a: adjusted for age and gender. Model b: adjusted for age, gender, disease duration, erythrocyte sedimentation rate, and health assessment questionnaire score. CI, confidence interval; NCEP, National Cholesterol Education Program; OR, odds ratio.

Toms et al. Arthritis Research & Therapy 2009 11:414   doi:10.1186/ar2806