Table 1

Models of arthritis

Model

Abbreviation

Species^a

Feature

IC

T cell

References

Trigger-induced models

Non-specific immune stimuli

Adjuvant-induced arthritis

AA

Lewis rat

Autoimmune

-

+

[1,2]

Oil-induced arthritis

OIA

DA rat

Autoimmune

-

+

[3]

Pristane-induced arthritis

PIA

DA rat

Autoimmune

-

+

[4,5]

Cartilage directed autoimmunity

Collagen-induced arthritis

CIA

DBA mouse

CII AI

+

+

[6,7]

Proteoglycan-induced arthritis

PGIA

Balb/c mouse

PG AI

+

+

[8,9]

Infectious agents/exogenous triggers

Streptococcal cell wall arthritis

SCW-A

Lewis rat

Persistent bacteria AI

-

+

[10]

Flare

SCW-F

Mouse

Th17

-

+

[11]

Antigen-induced arthritis

AIA

Rabbit, mouse

Persistent antigen

+

+

[12,13]

Flare

AIA-F

Mouse

Th17

-

+

[14]

Transgenic spontaneous models

HTLV-induced arthritis

HTLV

Mouse

Viral tax antigen

-

+

[15]

KRN arthritis

KRN

K/BxN mouse

GPI AI

+

+

[16,17]

SKG arthritis

SKG

Mouse

ZAP-70 T cell defect

-

+

[18,19]

GP130 arthritis

GP130

Mouse

STAT3, T cell defect

-

+

[20,21]

TNF transgenic arthritis

TNFtg

Mouse

TNF overexpression

-

-

[47,48]

IL-1ra transgenic arthritis

IL-1ra-/-

Balb/c mouse

Autoimmune T cells

±

+

[23]

IL-1 transgenic arthritis

IL-1tg

Mouse

IL-1 overexpression

-

-

[22]

Immune complex models

Collagen type II

CAIA

DBA mouse

Mouse CII antibody

+

-

[26,27]

KRN serum

GPI

Balb/c mouse

Mouse GPI antibody

+

-

[31]

Poly-L-lysine-lysozyme

PLL-L

DBA mouse

Cationic antigen

+

-

[28]

^aMost commonly used. AI = autoimmune; CAIA = collagen antibody-induced arthritis; GPI = glucose-6-phosphate isomerase; IC = immune complexes as an early feature; PG = proteoglycan.

Berg Arthritis Research & Therapy 2009 11:250   doi:10.1186/ar2803