Figure 3.

Major tissue destructive pathways in the rheumatoid joint. (a) Osteoclast differentiation and (b) fibroblast-like synoviocyte (FLS) proliferation. CX₃CR1, chemokine [C-X₃-C motif] receptor 1; FLS, fibroblast-like synoviocyte; HPC, hematopoietic progenitor cells; ICAM, intercellular adhesion molecule; LFA, lymphocyte function-associated antigen; LT, lymphotoxin; M, macrophage; MHC, major histocompatibility complex; RANKL, receptor activator of nuclear factor-κB ligand; SCF, stem cell factor; TCR, T-cell receptor; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.