Figure 1.

Estrogen actions on target articular tissues. ACL, anterior cruciate ligament; [Ca2+]i, intracellular calcium concentration; COX-2, cyclooxygenase-2; IGF, insulin-like growth factor; iNOS, inducible nitric oxide synthase; MRI, magnetic resonance imaging; OB, osteoblast; OVX, ovariectomized; PG, proteoglycan.

Roman-Blas et al. Arthritis Research & Therapy 2009 11:241   doi:10.1186/ar2791
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