Table 1 |
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|
Arthritis scores of type II collagen/complete Freund's adjuvant-immunized T-cell receptor transgenic mice and total splenocyte counts at day 28 |
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|
Mousea |
Cage |
Day 16b |
Day 20 |
Day 23 |
Day 27 |
Final score |
Category |
Total number of splenocytes |
|
|
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|
1 |
1 |
0,0,0,0 |
0,0,1,2 |
3,0,3,3 |
3,0,3,3 |
9 |
Severe |
8.00 × 107 |
|
3 |
1 |
0,0,0,0 |
0,0,0,1 |
0,1,0,0 |
3,3,0,0 |
6 |
Moderate |
1.66 × 108 |
|
4 |
1 |
3,0,1,0 |
3,3,1,1 |
3,3,3,3 |
3,3,3,3 |
12 |
Severe |
8.72 × 107 |
|
5 |
2 |
0,0,0,0 |
0,0,0,0 |
0,0,0,0 |
0,0,0,0 |
0 |
No arthritis |
1.47 × 108 |
|
6 |
2 |
0,0,0,0 |
0,0,0,0 |
0,0,0,0 |
0,0,0,0 |
0 |
No arthritis |
1.46 × 108 |
|
7 |
3 |
0,0,0,0 |
0,3,1,1 |
0,3,3,3 |
0,3,3,3 |
9 |
Severe |
1.05 × 108 |
|
8 |
3 |
0,2,0,0 |
1,3,0,0 |
1,3,0,0 |
1,3,0,1 |
5 |
Moderate |
1.66 × 108 |
|
9 |
3 |
0,0,0,0 |
0,0,0,0 |
0,0,0,0 |
0,0,1,1 |
2 |
Mild |
1.22 × 108 |
|
10 |
4 |
0,0,0,0 |
0,0,0,0 |
1,2,0,0 |
0,2,1,2 |
5 |
Moderate |
1.56 × 108 |
|
11 |
4 |
0,0,0,0 |
0,0,0,0 |
3,0,1,2 |
3,0,1,3 |
7 |
Severe |
5.52 × 107 |
|
12 |
5 |
0,0,0,0 |
0,0,1,0 |
0,0,1,0 |
0,0,1,0 |
1 |
Mild |
1.25 × 108 |
|
13 |
5 |
0,0,0,0 |
0,0,0,0 |
1,1,0,1 |
2,1,0,2 |
5 |
Moderate |
1.18 × 108 |
|
14 |
5 |
0,0,0,0 |
0,0,0,0 |
0,0,0,0 |
0,0,0,0 |
0 |
No arthritis |
7.12 × 107 |
|
15 |
6 |
0,0,0,0 |
0,0,0,0 |
0,0,0,1 |
0,3,1,3 |
7 |
Severe |
6.72 × 107 |
|
16 |
6 |
0,0,0,0 |
0,0,0,0 |
0,0,0,0 |
0,0,0,0 |
0 |
No arthritis |
8.32 × 107 |
|
17 |
6 |
0,0,0,0 |
0,0,0,0 |
0,0,1,0 |
0,0,3,1 |
4 |
Moderate |
8.00 × 107 |
|
18 |
7 |
0,0,0,0 |
0,0,0,0 |
1,2,0,1 |
1,3,1,3 |
8 |
Severe |
9.68 × 107 |
|
19 |
7 |
0,0,0,0 |
0,0,0,0 |
0,3,0,0 |
0,3,3,3 |
9 |
Severe |
6.40 × 107 |
|
20 |
7 |
0,0,0,0 |
0,0,1,1 |
0,0,2,3 |
0,0,2,3 |
5 |
Moderate |
8.72 × 107 |
|
|
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|
aMouse #2 was sacrificed at day 20 due to malnourishment, which was believed to be related to a dental abnormality. This mouse had no signs of arthritis on day 20. bArthritis disease scoring is based on a 3-point scale for each paw: 0 = no inflammation, 1 = inflammation confined to digits, 2 = mild swelling of paw, and 3 = severe swelling encompassing paw, ankle, wrist, and/or knee joints. Scores shown for individual dates are in the following order: right fore paw, left fore paw, right hind paw, and left hind paw. |
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|
Lundy and Fox Arthritis Research & Therapy 2009 11:R128 doi:10.1186/ar2795 |
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