Table 1

Apoptotic cell injection prevents rats from SCW-induced arthritis development

Acute phase (day 3)

Remission phase (days 10 and 11)

Chronic phase (days 24 to 30)

SCW + PBS

SCW + Apo

SCW + PBS

SCW + Apo

SCW + PBS

SCW + Apo

AI score^a

4.2 ± 0.8

2.0 ± 0.6

1.7 ± 0.7

0.5 ± 0.7

4.9 ± 3.5

1.3 ± 1.4

n

12

13

5

6

5

6

P value^b

0.041

0.052

0.030

Incidence^c

10/12

7/13

4/5

2/6

5/5

3/6

Pooled results from of three independent experiments. n, number of rats. ^aArticular index score presented as mean ± standard error of the mean. ^bCompared between streptococcal cell wall (SCW) and SCW + apoptotic cells (Apo); Mann-Whitney rank-sum test, one tail. ^cNumber of rats with disease among the rats of each group; the lower number of animals in the chronic phase is due to sacrifice of animals at the end of the acute phase in some experiments.

Perruche et al. Arthritis Research & Therapy 2009 11:R104   doi:10.1186/ar2750