Gout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link?
1 Birmingham VA Medical Center. 700 19th St S. Birmingham, AL 35233, USA
2 Division of Rheumatology, University of Florida. Gainesville, FL 32610, USA
3 Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, FOT 820, 1530 3rd Ave South, Birmingham, AL 35294, USA
Arthritis Research & Therapy 2009, 11:240 doi:10.1186/ar2761Published: 19 August 2009
An association between high levels of serum urate and cardiovascular disease has been proposed for many decades. However, it was only recently that compelling basic science data, small clinical trials, and epidemiological studies have provided support to the idea of a true causal effect. In this review we present recently published data that study the association between hyperuricemia and selected cardiovascular diseases, with a final conclusion about the possibility of this association being causal.