Table 2 |
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|
Factors affecting susceptibility/resistance to adjuvant arthritis |
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| Effector pathways/response |
Susceptibility/resistance (+/-) |
Rat strains tested |
References |
|
|
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| MHC and non-MHC genes including particular quantitative trait loci influence arthritis
susceptibility |
+/- |
Table 1 |
Table 1, [4,5] |
| Differential T-cell proliferative and/or cytokine response to Bhsp65, its arthritogenic
epitope 180 to 188, or its regulatory C-terminal determinants |
+/- |
LEW/WKY/Wistar/F344 |
[20,24,30,31,33,36] |
| Increased T-cell response to Rhsp65 and its regulatory epitopes |
- |
LEW/WKY |
[20,24,26] |
| Anti-Bhsp65/Rhsp65 antibody response induced upon Mtb challenge |
- |
LEW/BN/WKY/F344/Wistar |
[23,25,43] |
| Increased expression of hsp47 in the joints and enhanced anti-hsp47 antibodies in
rats with arthritis |
+ |
DA/AO |
[45] |
| Immune response to hsp71 |
- |
DA/AO/LEW |
[45,46] |
| Migration into and retention within the target organ (joints) of arthritogenic leukocytes;
the role of monocyte chemoattractant protein 1 and monocyte/macrophage chemotaxis |
+ |
LEW/WKY |
[19,20] |
| Increased reactive oxygen species contributing to arthritis resistance |
- |
DA/AO |
[10] |
| Blunted hypothalamic–pituitary–adrenal axis activity |
+ |
LEW/F344/Wistar |
[51,53-55] |
| Microbial flora in a conventional housing environment |
- |
F344/Wistar |
[56,59,60] |
|
|
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|
Bhsp65, mycobacterial heat-shock protein 65; hsp, heat-shock protein; MHC, major histocompatibility complex; Mtb, Mycobacterium tuberculosis H37Ra; Rhsp65, rat heat-shock protein 65. |
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Kim and Moudgil Arthritis Research & Therapy 2009 11:239 doi:10.1186/ar2755 |
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