arthritis-research.com

Table 1
Adjuvant arthritis-susceptible/resistant rat strains
Strain	Susceptibility to AA	MHC haplotype	References

Inbred rats
Lewis^a	+	RT-1^l	[21-24]
Dark Agouti	+	RT-1^av1	[45]
Piebald Viral Glaxo	+	RT-1^c/RT1^av1	[65]
Brown Norway^b	+/-	RT-1ⁿ	[23,33]
Fischer F344^c	+/-	RT-1^1vl	[59,60]
Wistar–Kyoto	-	RT-1^l	[24]
Wistar Albino Glaxo	-	RT-1^u	[42]
Buffalo	-	RT-1^b	[41]
Albino Oxford	-	RT-1^u	[45]
Outbred rats
Sprague Dawley^d	+	-	[66]
Holtzman^e	+	-	[41]
Wistar^f	+/-	-	[31,55,56]

MHC, major histocompatibility complex. ^aGenerally, male and female rats are comparable in their incidence of and the course of adjuvant arthritis (AA). In one study, however, higher sensitivity of female rats over male rats for complete Freund's adjuvant-induced inflammation and hyperalgesia has been reported [67]. ^bReported to be AA resistant in one study [23], but susceptible (males susceptible with moderate level of severity, but females resistant) in another study [33]. ^cFischer F344 rats can develop AA when bred and kept in a germ-free or barrier facility, but acquire resistance when bred and kept in a conventional environment. ^dOutbred rats; males develop AA of much greater severity than female rats. ^eOriginally derived from the Sprague Dawley rat. ^fOutbred rats with lines of rats showing susceptibility or resistance to AA.
Kim and Moudgil Arthritis Research & Therapy 2009 11:239 doi:10.1186/ar2755

Table 1