The determinants of susceptibility/resistance to adjuvant arthritis in rats
Department of Microbiology and Immunology, University of Maryland School of Medicine, HH 323C, 660 West Redwood Street, Baltimore, MD 21201, USA
Arthritis Research & Therapy 2009, 11:239 doi:10.1186/ar2755Published: 7 August 2009
Adjuvant arthritis (AA) serves as an excellent model for human rheumatoid arthritis. AA is readily inducible in certain rat strains, but not in others. Susceptibility/resistance to AA is determined by multiple factors. Among the genetic factors, both MHC and non-MHC genes contribute to arthritis susceptibility, and specific quantitative trait loci show association with the severity of the disease. Differential T-cell proliferative and cytokine responses, as well as antibody responses, to heat-shock proteins are evident when comparing AA-susceptible and AA-resistant rats. In addition, neuroendocrine factors and the housing environment can further modulate arthritis susceptibility/severity in particular rat strains.