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Editorial

Novel genetic analysis in Behçet's disease

Graham Wallace

Author Affiliations

Academic Unit of Ophthalmology, School of Immunity and Infection, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK

Arthritis Research & Therapy 2009, 11:123  doi:10.1186/ar2757


See related research article by Fei et al., http://arthritis-research.com/content/11/3/R66

Published: 5 August 2009

Abstract

Behçet's disease (BD) is characterized by oral and genital ulceration and is complicated by eye, skin, joint and central nervous system lesions. It has long been understood that BD has a strong genetic component, but to date the identified genes account for only around 30% of the risk for developing the disease, and the work has mostly been based on candidate gene analysis. In a recent report, Fei and coworkers presented the results of the first genome-wide analysis of patients with BD. These findings suggest new pathways for investigation in this complex disease.