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Editorial

New data favouring that neurotrophins are of importance in arthritis

Sture Forsgren

Author Affiliations

Department of Integrative Medical Biology, Anatomy Section, Umeå University, SE-901 87 Umeå, Sweden

Arthritis Research & Therapy 2009, 11:122  doi:10.1186/ar2754


See related research by Barthel et al., http://arthritis-research.com/content/11/3/R82

Published: 30 July 2009

Abstract

Neurotrophins are important in inflammation. In an article in Arthritis Research & Therapy, Barthel and collaborators give new information on the existence of neurotrophin production in the synovial tissue of arthritic joints. These findings, together with other recent findings, stress that neurotrophins should be considered important factors in arthritis. This is reinforced by the facts that they are also produced by articular chondrocytes and that receptors for these are present in the synovial tissue and on chondrocytes. The importance of neurotrophins in joints should be further studied, including examinations on the efficacy of interfering with their effects in arthritis.