Arthritis Research & Therapy

official impact factor 4.36

Open Access Research article

A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis

Elizabeth W Karlson1*, Lori B Chibnik1, Monica McGrath2, Shun-Chiao Chang3, Brendan T Keenan1, Karen H Costenbader1, Patricia A Fraser4,5, Shelley Tworoger2,3, Susan E Hankinson2,3, I-Min Lee3,6, Julie Buring3,6,7,8 and Immaculata De Vivo2

Author Affiliations

1 Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

2 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

3 Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA

4 Immune Disease Institute, 800 Huntington Avenue, Boston, MA 02115, USA

5 Genzyme Corporation, 500 Kendall Street, Cambridge, MA 02115, USA

6 Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

7 Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

8 Department of Ambulatory Care and Prevention, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA

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Arthritis Research & Therapy 2009, 11:R97 doi:10.1186/ar2742


See related editorial by Cutolo, http://arthritis-research.com/content/11/5/126

Published: 25 June 2009

Additional files

Additional file 1:

A Word file containing two tables that list the association of htSNPs in the AR gene and RA. Table S1 presents the association of the six htSNPs in the AR gene with RA in the NHS, in the WHS, and in the pooled sample. Table S2 presents the association of the six htSNPs in the AR gene with seropositive RA and seronegative RA in the NHS, in the WHS, and in the pooled sample.

Format: DOC Size: 61KB Download file

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