Aggrecan release after knee injury. Samples were ordered by time after knee injury (weeks) and by (a, b) meniscal injury alone (MEN) or (c, d) by anterior cruciate ligament rupture with or without an associated meniscus injury (ACL). Values are median concentrations of sulfated glycosaminoglycan (sGAG; open squares) and ARGS (filled squares) with 25th and 75th percentiles, compared with the medians (dashed lines) and 25th and 75th percentiles (shaded area) of the reference group on logarithmic Y-axes. Significant difference against the reference group at the 0.001 (***), 0.01 (**) and 0.05 (*) levels after Bonferroni correction is indicated.
Larsson et al. Arthritis Research & Therapy 2009 11:R92 doi:10.1186/ar2735