Table 2

Flow cytometric analysis of human chondrocytes derived from normal and OA-affected articular cartilage, cultured in monolayer for 24 hours (n = 10) and stained for Stro-1 and Notch-1

Percentage positive


Age and gender

OA grade†

Stro-1

Notch-1


Donor 1

53 male

1

25.1

6.1

Donor 2

17 female

1

9.5

4.3

Donor 3

65 male

1 to 2

nd*

14.0

Donor 4

61 male

2

26.5

2.8

Donor 5

30 male

2

54.6

1.6

Donor 6

56 female

2

29.1

3.4

Donor 7

65 female

2

nd

4.2

Donor 8

64 male

2 to 3

22.7

3.1

Donor 9

59 male

3 to 4

31.0

nd

Donor 10

64 male

3 to 4

5.9

2.5

Mean ± SE

25.6 ± 5.2

4.7 ± 1.2


† Grade 1 represents intact surface, Grade 2 minimal fibrillation, Grade 3 overt fibrillation and Grade 4 full thickness defect. *nd = not determined; OA = osteoarthritis; SE = standard error.

Grogan et al. Arthritis Research & Therapy 2009 11:R85   doi:10.1186/ar2719

Open Data