Synovial distribution pattern of 15-Lipoxygenase-1. CD163+ macrophages, CD31+ endothelial cells and prolyl 4-hydrolase-positive fibroblast cells express 15-lipoxygenase-1 (15-LO-1) in rheumatoid arthritis synovium. Photomicrographs showing fluorescent staining of (a) CD163+ cells, (b) CD31+ cells and (c) prolyl 4-hydrolase-positive cells (Alexa 546, red), 15-LO-positive cells (Alexa 488, green), and superimposed stainings. Original magnification: (a, b) ×200 and (c) ×400.
Gheorghe et al. Arthritis Research & Therapy 2009 11:R83 doi:10.1186/ar2717