Table 2 |
||
|
Candidate biomarkers identified in array screening experiments, subsequently used for training and cross-validation in PAM |
||
|
Variable |
Peptide sequence |
SwissProt ID |
|
|
||
|
Autoantigens |
||
|
Acetyl-calpastatin(184–203) |
Ace-DPMSSTYIEELGKREVTIPP- [NH]2 |
[Swiss-Prot:P20810] |
|
Apolipoprotein E(277–296)cit |
A [cit]LKSWFEPLVEDMQ [cit]QWAG |
[Swiss-Prot:P02649] |
|
Cfc(48–65)cit2 |
TIHAHPGS [cit]RGG [cit]HGYHH |
[Swiss-Prot:P20930] |
|
Clusterin(170–188) |
QTHMLDVMQDHFSRASSID |
[Swiss-Prot:P10909] |
|
Clusterin(334–353)cit2 |
AE [cit]LT [cit]KYNELLKSYQWKML |
[Swiss-Prot:P10909] |
|
Fibrinogen A(616–635)cit3 |
THSTK [cit]GHAKS [cit]PV [cit]GIHTS |
[Swiss-Prot:P02671] |
|
Fibromodulin(246–265) |
LEQLYMEHNNVYTVPDSYFR |
[Swiss-Prot:Q06828] |
|
H2B/e(1–20) |
MPEPVKSAPVPKKGSKKAIN |
[Swiss-Prot:Q16778] |
|
HSP60(287–297) |
VLNRLKVGLQV |
[Swiss-Prot:P10809] |
|
Osteoglycin(176–195) |
NQLLKLPVLPPKLTLFNAKY |
[Swiss-Prot:P20774] |
|
Serine protease 11(433–452) |
VIISINGQSVVSANDVSDVI |
[Swiss-Prot:Q92743] |
|
Biglycan(247–266) |
EDLLRYSKLYRLGLGHNQIR |
[Swiss-Prot:P21810] |
|
Cartilage oligomeric matrix protein(453–472) |
NSAQEDSDHDGQGDACDDDD |
[Swiss-Prot:P49747] |
|
Fibrinogen cit |
n.a. |
[Swiss-Prot:P02671] |
|
Cytokines and chemokines |
||
|
Eotaxin |
n.a. |
[Swiss-Prot:P51671] |
|
Fibroblast growth factor-2 |
n.a. |
[Swiss-Prot:P09038] |
|
Granulocyte- macrophage colony-stimulating factor |
n.a. |
[Swiss-Prot:P04141] |
|
IL-12p40 |
n.a. |
[Swiss-Prot:P29460] |
|
IL-12p70 |
n.a. |
[Swiss-Prot:P29459] |
|
IL-15 |
n.a. |
[Swiss-Prot:P40933] |
|
IL-1α |
n.a. |
[Swiss-Prot:P01583] |
|
IL-1β |
n.a. |
[Swiss-Prot:P01584] |
|
IL-6 |
n.a. |
[Swiss-Prot:P05231] |
|
IFNγ-inducible protein 10 |
n.a. |
[Swiss-Prot:P02778] |
|
TNFα |
n.a. |
[Swiss-Prot:P01375] |
|
Monocyte chemoattractant protein-1 |
n.a. |
[Swiss-Prot:P13500] |
|
|
||
|
n.a., not applicable; PAM, prediction analysis of microarrays. |
||
|
Hueber et al. Arthritis Research & Therapy 2009 11:R76 doi:10.1186/ar2706 |
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