Open Access Research article

Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts

Mária Pásztói1, György Nagy2, Pál Géher2, Tamás Lakatos2, Kálmán Tóth3, Károly Wellinger3, Péter Pócza1, Bence György1, Marianna C Holub1, Ágnes Kittel4, Krisztina Pálóczy1, Mercédesz Mazán1, Péter Nyirkos1, András Falus1,5 and Edit I Buzas1*

1 Department of Genetics, Cell and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest H-1089, Hungary

2 Department of Rheumatology, Semmelweis University, Frankel Leó utca 54, Budapest H-1027, Hungary

3 Department of Orthopedic Surgery, Szeged University, Semmelweis u.6, Szeged H-6725, Hungary

4 Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u. 43, Budapest H-1083, Hungary

5 Inflammation Biology and Immunogenomics Research Group, Hungarian Academy of Sciences-Semmelweis University, Nagyvárad tér 4, Budapest H-1089, Hungary

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Arthritis Research & Therapy 2009, 11:R68 doi:10.1186/ar2697

Published: 14 May 2009

Additional files

Additional data file 1:

An image file containing a figure demonstrating baseline glycosidase expression of SFs during passaging. The baseline glycosidase expression of SFs was tested at every second passage. There was no significant alteration of glycosidase gene expression from P1 to P9 passages either in OA (n = 6) or RA SFs (n = 5).

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