Table 3 |
|
|
Case-control analysis in German Caucasians |
|
|
(a) All individuals without controlling for LD with HLA-DRB1 |
|
|
Minor allele |
250A |
|
Allele frequency in cases/controls |
22%/33% |
|
Total alleles of RA cases/controls |
178/368 |
|
OR (95% CI) |
0.60 (0.4–0.9) |
|
OR P value |
0.016 |
|
(b) Subgroup without HLA-DRB1 risk alleles |
|
|
Frequency in cases/controls |
14%/34% |
|
Total alleles of RA cases/controls |
50/216 |
|
OR (95% CI) |
0.31 (0.1–0.7) |
|
OR P value |
0.005 |
|
(c) All individuals, controlling for LD with HLA-DRB1 by logistic regression |
|
|
OR (95% CI) |
0.6 (0.37–0.96) |
|
P value |
0.032 |
|
LRTa P value |
0.022 |
|
|
|
|
aLikelihood ratio test evaluating model including HLA-DRB1 alleles S2 and S3P and MICA-250 versus S2 and S3P only. For the HLA-DRB1 locus, allele L was used as reference. CI, confidence interval; LD, linkage disequilibrium; OR, odds ratio; RA, rheumatoid arthritis. |
|
|
Kirsten et al. Arthritis Research & Therapy 2009 11:R60 doi:10.1186/ar2683 |
|
