Table 3

Case-control analysis in German Caucasians

(a) All individuals without controlling for LD with HLA-DRB1

Minor allele

250A

Allele frequency in cases/controls

22%/33%

Total alleles of RA cases/controls

178/368

OR (95% CI)

0.60 (0.4–0.9)

OR P value

0.016

(b) Subgroup without HLA-DRB1 risk alleles

Frequency in cases/controls

14%/34%

Total alleles of RA cases/controls

50/216

OR (95% CI)

0.31 (0.1–0.7)

OR P value

0.005

(c) All individuals, controlling for LD with HLA-DRB1 by logistic regression

OR (95% CI)

0.6 (0.37–0.96)

P value

0.032

LRTa P value

0.022


aLikelihood ratio test evaluating model including HLA-DRB1 alleles S2 and S3P and MICA-250 versus S2 and S3P only. For the HLA-DRB1 locus, allele L was used as reference. CI, confidence interval; LD, linkage disequilibrium; OR, odds ratio; RA, rheumatoid arthritis.

Kirsten et al. Arthritis Research & Therapy 2009 11:R60   doi:10.1186/ar2683

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