Table 2

Association of MICA polymorphism within the second and combined first and second French Caucasian family cohort

2nd French family cohort

1st + 2nd French family cohort

(a) All individuals without controlling for LD with HLA-DRB1

Minor allele

A

A

Frequency in cases/controls^a

27%/32%

25%/33%

Minor allele transmitted/untransmitted

37/46

63/94

Transmission rate

45%

40%

TDT P value

0.328

0.015

(b) Subgroup without HLA-DRB1 risk alleles

Minor allele transmitted/untransmitted

12/16

18/34

Transmission rate

43%

35%

TDT P value

0.450

0.027

(c) All individuals, controlling for LD with HLA-DRB1 by conditional logistic regression

OR (95% CI)^b

0.68 (0.4–1.15)

0.56 (0.38–0.83)

P value

0.158

0.003

LRT^c P value

0.122

0.002

^aControls are non-transmitted alleles; ^bodds ratio of transmission of minor allele versus transmission of major allele as determined in logistic regression; ^clikelihood ratio test evaluating model including HLA-DRB1 alleles S2 and S3P and MICA-250 versus S2 and S3P only. For the HLA-DRB1 locus, allele L was used as reference. Effects of S2 and S3P alleles are presented in the online supplement (Additional data file 3). CI, confidence interval; LD, linkage disequilibrium; TDT, transmission disequilibrium test.

Kirsten et al. Arthritis Research & Therapy 2009 11:R60   doi:10.1186/ar2683