Table 1

Association of MICA polymorphisms within the first French Caucasian family cohort

MICA-210

MICA-250

MICA-300

(a) French population 1 – all individuals without controlling for LD with HLA-DRB1

Minor allele

4

5

5.1

6

9

A

A

Frequency in cases/controls^a

7%/12%

12%/7%

42%/36%

26%/25%

13%/20%

23%/34%

8%/4%

Minor allele transmitted/untransmitted

13/21

21/13

44/36

35/33

17/29

26/48

15/7

Transmission rate

38%

62%

55%

51%

37%

35%

68%

TDT P value

0.172

0.172

0.376

0.815

0.080

0.011

0.091

(b) French population 1, subgroup without HLA-DRB1 risk alleles

Minor allele transmitted/untransmitted

5/10

5/4

18/15

18/12

5/10

6/18

3/1

Transmission rate

33%

56%

55%

60%

33%

25%

75%

TDT P value

0.200

0.740

0.600

0.270

0.200

0.014

0.317

(c) French population 1, all individuals, controlling for LD with HLA-DRB1 by conditional logistic regression

OR (95% CI)^b

0.59

(0.25–1.34)

1.48

(0.64–3.54)

1.28

(0.77–2.16)

1.23

(0.71–2.17)

0.51

(0.24–1.05)

0.46

(0.25–0.82)

1.2

(0.37–4.15)

P value

0.235

0.428

0.379

0.518

0.072

0.007^d

0.944

LRT^c P value

0.165

0.319

0.314

0.433

0.048

0.005^d

0.728

^aControls are non-transmitted alleles; ^bodds ratio of transmission of minor allele versus transmission of major allele as determined in logistic regression; ^clikelihood ratio test evaluating model including HLA-DRB1 alleles S2 and S3P and MICA-250 versus S2 and S3P only. For the HLA-DRB1 locus, allele L was used as reference. ^dP value corrected for multiple testing less than 0.05. CI, confidence interval; LD, linkage disequilibrium; TDT, transmission disequilibrium test.

Kirsten et al. Arthritis Research & Therapy 2009 11:R60   doi:10.1186/ar2683