Open Access Research article

Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study

Holger Kirsten123, Elisabeth Petit-Teixeira4, Markus Scholz5, Dirk Hasenclever5, Helene Hantmann2, Dirk Heider6, Ulf Wagner7, Ulrich Sack28, Vitor Hugo Teixeira49, Bernard Prum10, Jana Burkhardt1, Céline Pierlot4, Frank Emmrich238, François Cornelis11124 and Peter Ahnert135*

Author Affiliations

1 Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, Deutscher Platz 5, 04103 Leipzig, Germany

2 Translational Centre for Regenerative Medicine, University of Leipzig, Philipp-Rosenthal-Str. 55, 04103 Leipzig, Germany

3 Fraunhofer Institute for Cell Therapy and Immunology IZI, Perlickstr. 1, 04103 Leipzig, Germany

4 GenHotel-EA3886, Evry-Paris VII Universities, 2 rue Gaston Crémieux, 91057 Evry-Genopole cedex, France

5 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Härtelstr. 16-18, 04107 Leipzig, Germany

6 Health Economics Research Unit, Department of Psychiatry, University of Leipzig, Liebigstr. 26, 04103 Leipzig, Germany

7 Medical Clinic and Polyclinic IV, University Hospital Leipzig, Liebigstr. 22, 04103 Leipzig, Germany

8 Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany

9 Faculty of Medicine, University of Coimbra, Rua Larga, 3004-504 Coimbra, Portugal

10 Statistics and Genome laboratory, La genopole, 523 place des Terrasses, 91000 Evry, France

11 Hôpital Sud Francilien, 59 Boulevard Henri Dunant, 91106 Corbeil-Essonnes cedex, France

12 Hôpital Lariboisière, AP-HP, 2 rue Ambroise – Paré, 75475, Paris cedex 10, France

For all author emails, please log on.

Arthritis Research & Therapy 2009, 11:R60  doi:10.1186/ar2683

Published: 1 May 2009

Additional files

Additional data file 1:

A table listing the distribution of HLA-DRB1 alleles in the analyzed RA cohorts.

Format: PDF Size: 55KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 2:

Background information for the conditional logistic regression method applied for family based analysis.

Format: PDF Size: 80KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 3:

A table providing detailed results of conditional logistic regression models of all French families.

Format: PDF Size: 11KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 4:

A table providing detailed results of logistic regression models of the German case control cohort.

Format: PDF Size: 21KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 5:

A table providing a representation of association analysis in all informative families controlling for LD with DRB1.

Format: PDF Size: 20KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data