Nucleus pulposus cells as competent phagocytes to clear apoptotic cells: mission applicable or impossible?
Institute of Orthopaedics, Xijing Hospital, #17 Changle Western Road, Fourth Military Medical University, Xi'an 710032, PR China
Arthritis Research & Therapy 2009, 11:405 doi:10.1186/ar2647
See related research article by Jones et al., http://arthritis-research.com/content/10/4/R86, and related letter by Jones et al., http://arthritis-research.com/content/11/3/406Published: 6 May 2009
First paragraph (this article has no abstract)
We have read with interest the research article by Philip Jones and colleagues, in which they studied whether bovine nucleus pulposus (NP) cells were capable of behaving as phagocytes . Collectively, they drew the conclusion that disc cells clearly can undergo phagocytosis, which has implications for the intervertebral disc in vivo. We would like to differ from the authors, however, regarding the implications of the role of NP cells in vivo in comparison with in vitro as competent phagocytes to ingest apoptotic cells.