Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new?
1 Department of Pediatric Immunology, Wilhelmina Children's hospital, UMCU, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
2 Eureka Institute for Translational Medicine, Viale Teracati 50a, 96100, Siracusa, Italy
3 The University of Arizona College of Medicine, 1501 N. Campbell Avenue, PO BOX 245093, Tucson, AZ, USA
Arthritis Research & Therapy 2009, 11:231 doi:10.1186/ar2674Published: 19 May 2009
Juvenile idiopathic arthritis (JIA) is a disease characterized by chronic joint inflammation, caused by a deregulated immune response. In patients with JIA, heat shock proteins (HSPs) are highly expressed in the synovial lining tissues of inflamed joints. HSPs are endogenous proteins that are expressed upon cellular stress and are able to modulate immune responses. In this review, we concentrate on the role of HSPs, especially HSP60, in modulating immune responses in both experimental and human arthritis, with a focus on JIA. We will mainly discuss the tolerogenic immune responses induced by HSPs, which could have a beneficial effect in JIA. Overall, we will discuss the immune modulatory capacity of HSPs, and the underlying mechanisms of HSP60-mediated immune regulation in JIA, and how this can be translated into therapy.