Table 2

Effect of interleukin-17 in arthritis

In vitro

In vivo


Inflammation

Neutrophilic response

IL-17-deficient mice

Stimulation of G-CSF production

Attenuated form of CIA

Stimulation of CXCL1, Groα (mouse)

Protected from arthritis in IL-1Ra-deficient mice

CXCL8 (human)

No effect in PIA

T-cell and DC recruitment

CCL20 production

IL-1 and TNF-α production by macrophages

IL-6, PGE2 production by synovial fibroblasts

NO in articular chondrocytes

Tissue destruction

Production of MMPs

Intra-articular IL-17 induces cartilage degradation

Local IL-17 gene transfer induces MMPs and high RANKL/OPG ratio and osteoclastogenesis

Joint destruction is dependent on IL-17R signalling in radiation-resistant cells in SCW arthritis


CIA, collagen-induced arthritis; DC, dendritic cell; G-CSF, granulocyte colony-stimulating factor; IL, interleukin; IL-1Ra, interleukin-1 receptor antagonist; MMP, matrix metalloproteinase; NO, nitric oxide; OPG, osteoprotegerin; PGE2, prostaglandin E2; PIA, proteoglycan-induced arthritis; RANKL, receptor activator of nuclear factor-kappa-B ligand; SCW, streptococcal cell wall-induced; TNF-α, tumour necrosis factor-alpha.

Gabay and McInnes Arthritis Research & Therapy 2009 11:230   doi:10.1186/ar2680