Table 1

Human interleukin-17 and interleukin-17 receptor family

Ligands (alternative names)

Produced mainly by

Binding receptors

Tissue expression of receptors


IL-17 (IL-17A)

T cells (Th17)

IL-17RA

Widely expressed

IL-17RC

Cartilage, synovial tissue, brain, heart, small intestine, kidney, lung, colon, liver, skeletal muscle, placenta, prostate, low expression in thymus

IL-17A/IL-17F

T cells (Th17)

IL-17RA

IL-17RC

IL-17B

Adult pancreas, small intestine, stomach

IL-17RB

Several endocrine tissues, liver, kidney, pancreas, testis, brain, colon, small intestine, not detected in lymphoid organs and peripheral leucocytes

IL-17C

Prostate, foetal kidney

Unknown

IL-17D

Adipose tissue, skeletal muscle, CNS

Unknown

IL-17E (IL-25)

CNS, kidney, lung, prostate, testis, adrenal gland, trachea

IL-17RA

IL-17RB

IL-17F

T cells (Th17)

IL-17RA

IL-17RC

Unknown

IL-17RD (SEF homologue)

Endothelial cells, kidney, colon, skeletal muscle, heart, salivary glands, seminal vesicles, small intestine

Unknown

IL-17RE

Tumour cell lines


CNS, central nervous system; IL, interleukin; SEF, similar expression to fibroblast growth factors.

Gabay and McInnes Arthritis Research & Therapy 2009 11:230   doi:10.1186/ar2680