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Highly Accessed Review

Developments in the scientific understanding of osteoporosis

Nancy E Lane* and Wei Yao

Author Affiliations

Aging Center, Medicine and Rheumatology, Department of Medicine, University of California at Davis Medical School, Sacramento, CA 95817, USA

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Arthritis Research & Therapy 2009, 11:228  doi:10.1186/ar2656

Published: 19 May 2009

Abstract

During the past 10 years we have experienced very significant developments in our understanding of bone biology, and this has improved our abilities to both diagnose and treat patients with osteoporosis. This review covers some of the significant discoveries in bone biology that have led to a better understanding of osteoporosis, including a few of the discoveries that have been translated into new therapies to treat patients with osteoporosis and the structural deterioration of patients with inflammatory arthritis.