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Editorial

The quest for a biomarker of circulating osteoclast precursors

Christopher Ritchlin

Author Affiliations

University of Rochester Medical Center, Rochester, NY 14642, USA

Arthritis Research & Therapy 2009, 11:113  doi:10.1186/ar2707


See related research by Lari et al., http://arthritis-research.com/content/11/1/R23

Published: 17 June 2009

Abstract

Osteoclast precursors arise from the CD14+ CD16- population in controls but details about cell surface marker expression and functional characteristics of these cells is unknown, particularly in patients with inflammatory arthritis. In a recent issue of Arthritis, Research and Therapy, Lari and colleagues found that osteoclasts developed from a proliferative CD14+ CD16- subset in healthy controls. These cells took on the morphology of osteoclasts, expressed mRNA for osteoclast-related genes and excavated pits on bone wafers. These findings provide new insights into monocyte diversity and provide evidence that osteoclast precursors arise from a small proliferating monocyte population in controls. Additional studies are needed in patients with inflammatory arthritis