Research article
Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis
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* Corresponding author: Bernard R Lauwerys bernard.lauwerys@uclouvain.be
1 Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Avenue Hippocrate 10, B-1200 Brussels, Belgium
2 Rheumatology Department, CHU Brugmann, Place Arthur Van Gehuchten 4, 1020 Brussels, Belgium
3 Pathology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Avenue Hippocrate 10, B-1200 Brussels, Belgium
4 Ludwig Institute for Cancer Research, Avenue Hippocrate 74, B-1200 Brussels, Belgium
Arthritis Research & Therapy 2009, 11:R57 doi:10.1186/ar2678
Published: 23 April 2009Additional files
Additional file 1:
A table listing the genes differentially expressed between T0 and T12 in the synovium of adalimumab-treated RA patients. Microarray data were analyzed on TMEV 4.0 after elimination of the genes with a flag absent in more than half the samples and selection of the 8,000 genes that displayed the widest inter-individual variations. In all patients, 254 genes were found to display significant differences in expression between T0 and T12 using Student's t-tests. Fold changes are the ratio between mean expression at T0 above mean expression at T12.
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