Figure 6.

Temporal changes in gene expressions in the salivary glands of C57BL/6.NOD-Aec1Aec2 mice for genes associated with clearance of apoptotic cells. (a) Model of the proposed mechanism for the (lack of) clearance of apoptotic cell debris by phagocytic cells, resulting in reduced interleukin-2 (IL-2) production by phagocytic cells. (b) Expression of genes associated with apoptotic cell clearance. Expression profiles are presented for these genes at 8, 12, 16, and 20 weeks of age relative to 4 weeks of age. Aec, autoimmunexocrinopathy; AP-1, activation protein-1; CR, complement receptor; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factor-kappa-B; NOD, non-obese diabetic.