Figure 1.

Map of the studied region in chromosome 6q23. Recombination hot-spots from the HapMap CEU data are represented as black squares below the rule showing physical distances along the chromosome in kilobases. The positions of the two rheumatoid arthritis-associated peak single nucleotide polymorphisms from previous studies (rs13207033 and rs6920220) are marked by arrowheads. The position of the TNFAIP3 gene and its structure are shown.