Arthritis Research & Therapy

official impact factor 4.36
Search for
Advanced search
Arthritis Research & Therapy
Tools
Share this article
Open Access Research article

Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-κB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility

Rebeca Dieguez-Gonzalez1, Manuel Calaza1, Eva Perez-Pampin1, Alejandro Balsa2, Francisco J Blanco3, Juan D Cañete4, Rafael Caliz5, Luis Carreño6, Arturo R de la Serna7, Benjamin Fernandez-Gutierrez8, Ana M Ortiz9, Gabriel Herrero-Beaumont10, Jose L Pablos11, Javier Narvaez12, Federico Navarro13, Jose L Marenco14, Juan J Gomez-Reino1,15 and Antonio Gonzalez1*

Author Affiliations

1 Laboratorio de Investigacion 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, 15706, Spain

2 Rheumatology Unit, Hospital La Paz, Madrid, 28046, Spain

3 Laboratorio de Investigación Osteoarticular y del Envejecimiento, Servicio de Reumatología, Hospital Universitario Juan Canalejo, A Coruña, 15006, Spain

4 Arthritis Unit, Rheumatology Department, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi I Sunyer, Barcelona, 08036, Spain

5 Rheumatology Unit, Hospital Universitario Virgen de las Nieves, Granada, 18001, Spain

6 Rheumatology Unit, Hospital Universitario Gregorio Marañon, Madrid, 28007, Spain

7 Rheumatology Unit, Hopital Santa Creu e San Pau, Barcelona, 08025, Spain

8 Rheumatology Unit, Hospital Clinico San Carlos, Madrid, 28040, Spain

9 Rheumatology Unit, Hospital Universitario La Princesa, Madrid, 28006, Spain

10 Rheumatology Unit, Fundación Jimenez Diaz, Madrid, 28040, Spain

11 Rheumatology Unit, Hospital 12 de Octubre, Madrid, 28041, Spain

12 Rheumatology Unit, Hospital Universitario de Bellvitge, Barcelona, 08907, Spain

13 Rheumatology Unit, Hospital Univesitario Virgen Macarena, Sevilla, 41003, Spain

14 Rheumatology Unit, Hospital Universitario de Valme, Sevilla, 41014, Spain

15 Department of Medicine, University of Santiago de Compostela, Santiago de Compostela, 15705, Spain

For all author emails, please log on.

Arthritis Research & Therapy 2009, 11:R42 doi:10.1186/ar2650


See related editorial by Maxwell et al, http://arthritis-research.com/content/11/2/107

Published: 17 March 2009

Additional files

Additional file 1:

A Microsoft Word document that contains the following tables: Table S1 (distribution of samples by recruitment hospital), Table S2 (details of the SNPs that were studied and the oligonucleotides that were used), Table S3 (conditional analysis between the rs582757 SNP and the most common haplotype in the TNFAIP3 locus), Table S4 (results for each SNP stratified by ACPA or RF status), and Table S5 (haplotype analysis of the SNPs in the intergenic 6q23 region).

Format: DOC Size: 309KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data