Table 1

Histological score of femoral condyles and tibial plateaus of placebo and ASU-treated dogs

Treatment group

Structure (0 to 30)a

Tangential (0 to 6)a

Transitional (0 to 30)a

Safranin-O staining (0 to 12)a

Pannus (0 to 9)a

Total (0 to 87)a


Femoral condyles

Placebo

20.50 ± 0.92

5.75 ± 0.19

15.63 ± 0.70

4.69 ± 0.33

0.88 ± 0.24

47.55 ± 1.74

ASU (10 mg/kg)

11.44 ± 0.90 (P < 0.0001)

3.81 ± 0.25 (P < 0.0001)

12.88 ± 0.42 (P = 0.006)

3.69 ± 0.24 (P = 0.03)

0.19 ± 0.10 (P = 0.004)

32.31 ± 1.64 (P < 0.0001)

Tibial plateaus

Placebo

20.69 ± 0.64

5.75 ± 0.14

16.88 ± 0.79

4.75 ± 0.40

1.75 ± 0.34

49.81 ± 1.86

ASU (10 mg/kg)

13.25 ± 1.52 (P < 0.0001)

4.19 ± 0.28 (P = 0.0002)

13.06 ± 0.55 (P = 0.001)

4.25 ± 0.31

1.62 ± 0.36

36.38 ± 2.07 (P = 0.0002)


The score was determined as described in the Materials and methods section. The final score corresponds to the sum of the scores obtained for the three subregions. Data are expressed as mean ± standard error of the mean and were analyzed using Mann-Whitney two-tailed U-test. Comparison was performed with the autologous placebo and P = 0.05 is considered statistically significant. aThe values given in parentheses indicates the range for each measure. ASU, avocado/soybean unsaponifiables.

Boileau et al. Arthritis Research & Therapy 2009 11:R41   doi:10.1186/ar2649

Open Data