5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population

doi:10.1186/ar2606

Arthritis Research & Therapy

Volume 11
Issue 2

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Kirsten H
Burkhardt J
Hantmann H
Hunzelmann N
Vaith P
Ahnert P
Melchers I

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Melchers I
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Letter

5HT_2Apolymorphism His452Tyr in a German Caucasian systemic sclerosis population

Holger Kirsten¹^,2^,3^* , Jana Burkhardt¹^* , Helene Hantmann² , Nico Hunzelmann⁴ , Peter Vaith⁵ , Peter Ahnert¹^,6 and Inga Melchers⁷

¹Institute of Clinical Immunology and Transfusion Medicine, Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, Johannisallee, 04103 Leipzig, Germany

²Fraunhofer Institute for Cell Therapy and Immunology, Perlickstr., 04103 Leipzig, Germany

³Translational Center for Regenerative Medicine, University of Leipzig, Phillip-Rosenthal-Str., 04103 Leipzig, Germany

⁴Department of Dermatology, University of Cologne, Kerpener Straße, 50924 Cologne, Germany

⁵Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Hugstetter Str., 79106 Freiburg, Germany

⁶Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstr. 16-18, 04107 Leipzig, Germany

⁷Clinical Research Unit for Rheumatology, University Medical Center, Breisacher Str., 79106 Freiburg, Germany

author email corresponding author email* Contributed equally

Arthritis Research & Therapy 2009, 11:403doi:10.1186/ar2606


Published:	26 March 2009

See related research by Beretta et al., http://arthritis-research.com/content/10/5/R103 and related letter by Beretta and Scorza, http://arthritis-research.com/content/11/2/404

First paragraph (this article has no abstract)

Recently, Beretta and colleagues [1] reported a protective association of the serotonin 5-HT_2Areceptor gene polymorphism His452Tyr (C+1354T, rs6314) with systemic sclerosis (SSc) in an Italian population. 5HT_2Aaccounts for most vasoconstrictive and platelet aggregation due to serotonin activity [2]. Beretta and colleagues also demonstrated that plasma from healthy heterozygous carriers of His452Tyr showed decreased platelet aggregation after serotonin stimulus compared to plasma from healthy individuals homozygous for His452. In consequence, they suggested a functional role of His452Tyr in reducing susceptibility to SSc.