5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population
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* Corresponding author: Inga Melchers Inga.melchers@uniklinik-freiburg.de
- † Equal contributors
1 Institute of Clinical Immunology and Transfusion Medicine, Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, Johannisallee, 04103 Leipzig, Germany
2 Fraunhofer Institute for Cell Therapy and Immunology, Perlickstr., 04103 Leipzig, Germany
3 Translational Center for Regenerative Medicine, University of Leipzig, Phillip-Rosenthal-Str., 04103 Leipzig, Germany
4 Department of Dermatology, University of Cologne, Kerpener Straße, 50924 Cologne, Germany
5 Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Hugstetter Str., 79106 Freiburg, Germany
6 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstr. 16-18, 04107 Leipzig, Germany
7 Clinical Research Unit for Rheumatology, University Medical Center, Breisacher Str., 79106 Freiburg, Germany
Arthritis Research & Therapy 2009, 11:403 doi:10.1186/ar2606
Published: 26 March 2009First paragraph (this article has no abstract)
Recently, Beretta and colleagues [1] reported a protective association of the serotonin 5-HT2A receptor gene polymorphism His452Tyr (C+1354T, rs6314) with systemic sclerosis (SSc) in an Italian population. 5HT2A accounts for most vasoconstrictive and platelet aggregation due to serotonin activity [2]. Beretta and colleagues also demonstrated that plasma from healthy heterozygous carriers of His452Tyr showed decreased platelet aggregation after serotonin stimulus compared to plasma from healthy individuals homozygous for His452. In consequence, they suggested a functional role of His452Tyr in reducing susceptibility to SSc.