Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
1 Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Room LU104, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
2 Respiratory Medicine Division, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospitals, Box157, Hills Road, Cambridge, UK, CB2 2QQ
Arthritis Research & Therapy 2009, 11:219 doi:10.1186/ar2632Published: 21 April 2009
With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed.